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Transplantation of wild-type subcutaneous WAT ameliorates hyperglycemia of Insr P1195L/ + /HFD mice P1195L/ + To assess the involvement of increased lipolysis in WAT of Insr P1195L/ +/HFD mice on the development of hyperglycemia, we transplanted wild-type subcutaneous WAT to Insr P1195L/ + mice

These four mechanisms operate on distinct molecular targets, which minimizes theoretical pathway competition and provides the rationale for multi-component research models

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