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Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure

Nicoll RA, Malenka RC (1995)

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The expression of the PD-1 molecule, which is observed in many cell populations, in contrast to the limited occurrence of other molecules belonging to the CD28 superfamily of molecules to T lymphocytes, suggests that the PD-1 receptor plays a major role in the regulation of the immune response [131]

A final rule entitled Modernizing and Clarifying the Physician Self-Referral Regulations (the MCR final rule) appeared in the December 2, 2020 Federal Register (85 FR 77492) and established three new exceptions to the physician self-referral law applicable to compensation arrangements that qualify as value-based arrangements, established exceptions for limited remuneration to a physician and the donation of cybersecurity technology and services, and revised or clarified several existing exceptions