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In contrast to other metabolic transformations, acetylation ends with less polar metabolite compared to the parent drug In some cases, the acetylated metabolite will be as active as the original drug

References: Allen et al

These changes suggest ARA-290 may influence metabolic function through its anti-inflammatory effects, since chronic inflammation contributes significantly to insulin resistance and dyslipidemia

Many experiments showed that the regulation of sulfate uptake is well correlated with regulation of mRNA levels of the transporters, in particular those of group 1 (Smith et al., 1997