Es investigacin preclnica (modelos animales)
focused on changes in weight, hirsutism scores, menstrual cycles, endocrine-metabolic profiles, and other factors in adolescent patients with PCOS with low birth weight (LBW) and precocious pubarche (PP) who received metformin treatment at different stages
Express USA time frame: 10-21 business days
Cell 38 GaoS.LiuJ.HanY.DejiQ.ZhabaW.DengH.et al (2020)
Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models
