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Autism spectrum disorders: developmental disconnection syndromes

Kristensen 1987

Across this interface, there is: (a) a physical barrier formed by tight junctions between cells (visualized in Figure 4), (b) a barrier to transport, as a result of ion channels and other means of modulating solute flux, and (c) a metabolic barrier created by a suite of enzymes, which metabolize molecules that they contact

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The synovium that lines the knee joint capsule, producing synovial fluid to lubricate the joint and reduce friction, can become inflamed, thickening the capsule