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The first step is to measure cardiovascular risk more accurately, think in cumulative exposure rather than only 10-year horizons, use apoB where possible and especially where standard markers are most likely to underrepresent risk, intervene earlier when trajectory, family history, metabolic phenotype, or imaging suggest that the risk is being understated, and keep treatment burden proportional to the quality of evidence and the person in front of the doctor

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Furthermore, butyrate, which is one of the SCFAs, can inhibit NF-B activation, HDACs, and upregulate PPAR- [149], demonstrating anti-inflammatory and oxidative stress-modulating effects

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