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Ewing, B

Discovered in 2015 by Changhan David Lee and Pinchas Cohen at USC, MOTS-c is encoded in the 12S rRNA region of the mitochondrial genomemaking it one of a small but growing family of mitochondrial-derived peptides (MDPs) that challenge the longstanding view of mitochondria as passive energy factories

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

10.1016/j.jaci.2005.12.1331 101 GuH.AnH.-J.KimJ.-Y.KimW.-H.GwonM.-G.KimH.-J.et al (2019)

For example, mesenchymal-specific TNFR1 triggering is indispensable for arthritis development in acute and chronic TNF-dependent mouse models