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Effects of nicotine and E-cigarette fluids on cytochromes P450 in Hcmec/D3 blood-brain barrier cell line

Importantly, oxidative stress resulting from the gas- or tar-phase derived ROS can be augmented by a defect or saturated antioxidant defense system, or as a consequence of additional ROS or other reactive metabolites generated through biotransformation of tobacco smoke chemicals inhaled by smokers [49, 61]

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