Rickettsia rickettsiae Parasitic Liver flukesa Heartworms and caval syndrome Drugs and Anesthetics Anticonvulsants and Sedatives Antiinflammatory and Analgesic Drugs Glucocorticoids (dogs) Acetaminophen (dogs and cats) Carprofen and other nonsteroidal antiinflammatory drugs (dogs) Antimicrobials and Parasiticides Diethylcarbamazine (dogs) Doxycycline (dogs) Griseofulvin (cats) Itraconazole (dogs and cats) Ketoconazole (dogs and cats) Mebendazole (dogs) Oxibendazole (dogs) Sulfonamides (dogs) Terbinafine (dogs) Tetracycline (dogs and cats) Thiacetarsamide (dogs) Anesthetics Halothane (dogs) Methoxyflurane (dogs) Miscellaneous Herbal and Dietary Supplements Biologic Toxins Aflatoxin Amanita mushrooms Blue-green algae Cycads (Sago palms) Hornet stings Indigofera linnaei (legume) Food Additives Xylitol (sugar substitute)(dogs) Chemicals Carbon tetrachloride Dimethylnitrosamine Dinitrophenol Pine oil Heavy metals (e.g., copper, lead, iron, arsenic) Organochloride pesticides Phenols Many others Metabolic Disorders Acute pancreatitis Hemolytic anemia and disseminated intravascular coagulation Hepatic copper accumulationa Inflammatory bowel disease Feline hepatic lipidosis Neoplastic Disorders Carcinoma (biliary, pancreatic) Lymphoma Malignant histiocytosis Hypoxic/Ischemic Disorders Shock Liver lobe torsion Thromboembolic disease Congestive heart failure Miscellaneous Trauma Heat stroke History of Dogs and Cats with Liver Disease A properly taken history is pivotal to defining the most clinically relevant problems that need to be resolved

Accessed 2/10/2022, Herati AS, Kohn TP, Kassiri B

(12)Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin (12) Preparation of Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin (11)Fmoc-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin(20DMF)5203DMF3DMF2Fmoc-Pro-OH0.8gDIEA0.4mlTBTU0.56gHOBT0.2gDMF10ml1.53DMF3DMF2Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin In step (11) of Fmoc-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin, add decapping reagent (20% piperidine DMF solution), reacted at room temperature for 5 minutes, drained, added decapping agent and reacted at room temperature for 20 minutes, washed 3 times with isopropanol, washed 3 times with DMF, washed 2 times with re-distilled DMF, drained, added Fmoc- Pro-OH0.8g, DIEA0.4ml, TBTU0.56g, HOBT0.2g, DMF10ml, react at room temperature for 1.5 hours, dry with vacuum pump, wash with isopropanol for 3 times, DMF for 3 times, and distilled DMF for 2 times , drained to obtain Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin

Carcinogenesis 28(5):962967 Raines AL et al (2010) Regulation of angiogenesis during osseointegration by titanium surface microstructure and energy
doi: 10.1161/hh2401.101070