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Therefore, well-designed in vivo studies, incorporating long-term neuro-developmental follow-up, are essential to rigorously evaluate the therapeutic potential of L-carnitine/acetyl-L-carnitine in protecting the vulnerable developing brain following HIE (86)

6F), indicating that VITE improved GPX4 expression but not TP53, thereby protecting iron-overloaded mice from infertility

Louwies, C

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Before advancing these strategies to clinical application, several key challenges must be addressed, such as the complexity and functional redundancy of the ferroptosis regulatory network, the limitations of existing animal models in simulating the pathological features of human chronic OA, and the lack of reliable biomarkers for assessing intra-articular ferroptosis activity in humans