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Furthermore, a retrospective study of 147 lung cancer patients with MET exon 14 mutations revealed a 17% ORR and a mPFS of just 1.9 months post-immunotherapy [122]

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Therefore, developing a comprehensive therapeutic platform capable of spatiotemporal ROS scavenging, regulation of macrophage polarization, and enhancement of angiogenesis and cell proliferation represents a critical research focus for improving clinical outcomes in chronic diabetic wound management

No matter how high the drug concentration goes, a point will be reached beyond which no further increment in response is achieved