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As by-products of normal aerobic metabolism, ROS can activate various mitochondrial signaling pathways, such as Nrf2/HIF-1/NF-B, even at low concentrations [79]

Figure 1 presents a flowchart depicting the study selection

3.3 CK19-related techniques CK19 is a type of cytokeratin with a relatively small molecular weight that is commonly expressed in both normal epithelial cells and epithelial-origin tumors (74)