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Catch-up of growth after glucocorticoid excess: A mechanism intrinsic to growth plate

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Genetic variants associated with uric acid levels mainly include purine metabolism (e.g., XDH, HPRT1), urate transporters (e.g., SLC2A9, SLC22A12), and renal urate processing regulators (e.g., ABCG2)

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Commonly reported adverse effects include: Injection site reactions (redness, pain, swelling) Fluid retention (peripheral oedema, joint pain, or carpal tunnel syndrome) related to GH-mediated effects Glucose metabolism changes : tesamorelin can raise blood glucose levels and may worsen insulin resistance