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Activation of these sensors triggers PI3K/Akt signaling and eNOS activation, increasing NO production as well as promotion of nuclear factor erythroid 2-like 2 (Nrf2), responsible for antioxidant gene expression [206]

LiY.H.ItoK.TsudaY.KohdaR.YamadaH.ItohT.1999Mechanism of Intestinal Absorption of an Orally Active -Lactam Prodrug: Uptake and Transport of Carindacillin in Caco-2 Cells.2903958964

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Genomics 28 , 301310 (2007)