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Front Pharmacol 9:1371 Lee N, Carlisle AE, Peppers A, Park SJ, Doshi MB, Spears ME, Kim D (2021) xCT-driven expression of GPX4 determines sensitivity of breast cancer cells to ferroptosis inducers

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A dose-dependent elevation in MDA levels and reduction in non-enzymatic (GSH) and enzymatic (CAT, SOD, and GPx) antioxidant levels were observed in the dams of Ara-C groups as compared to the dams of the control group (Fig

This review synthesizes the mechanistic foundations of hypoxia-induced metabolic reprogramming, its role in tumor progression and therapeutic resistance, and discusses innovative strategies aimed at exploiting hypoxia-associated metabolic dependencies to advance precision oncology