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Overexpression of SOD1 has been linked to the neural disorders seen in Down syndrome

NLRP3 inflammasome regulates release of IL-18 and IL-1 (pro-inflammatory cytokines) in macrophages and gets activated on receiving damage-associated molecular patterns (79)

*Correspondence: Jan Tauchen, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers