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The questions typically cover topics such as the number of cigarettes smoked per day, the time to the first cigarette after waking up, and perceived difficulty in refraining from smoking in various situations

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232 were excluded as they were reviews, 138 were cell or animal studies, 36 were not focused on PD, 19 did not study specific environmental exposures, 16 did not test any epigenetic markers, six were book chapters, six were conference reports of previously excluded papers and four were meta-analyses (Fig