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GLUTATHIONE PEROXIDASE PLAYS A CONTRADICTORY ROLE IN HYPERTENSION With respect to hypertension, glutathione peroxidase (GPx) has important functions in the reduction of peroxides that are reported to inactivate vasodilating NO and the decomposition of S-nitrosoglutathione (GSNO), which plays an important role in vascular homeostasis (33)

The biological evidence is robust at the cellular level, and clinical results are promising but limited by small study sizes, industry sponsorship, and absence of independent replication

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