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Such symptoms have resulted from the over-stimulation of the thyroid due to the induction of hyperthyroidism through exogenous thyroid hormones and in turn cause excessive secretion of thyroid hormones, which disturb the feedback loop of the hypothalamic-pituitary-thyroid axis (Bao et al

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The model also correctly simulates the metabolic profile of autism when oxidative stress is substantially increased and the adenosine concentration is raised