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The prominent lymphocytic inflammationat least in the earlier relapsing phase of the diseaseis traditionally thought to be the primary insult with immune cells recruited into the CNS to induce recurrent chronic injury (Box 1)

A number of studies have demonstrated a close association between PD-related genes and mitochondrial integrity

CAS 62568-57-4) was isolated in 1977 by Schoenenberger, Monnier and colleagues at the University of Basel from the cerebral venous blood of rabbits subjected to hypnogenic electrical stimulation of the intralaminar thalamus, and named for the slow-wave (delta) EEG activity it appeared to enhance after intraventricular infusion in recipient rabbits (Schoenenberger & Monnier, 1977)

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