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3DVA performed on the particle stacks from the initial larger dataset revealed that ECL3 is dynamic, consistent with the identification of two slightly differing ECL3 conformations from individual experiments (discussed in more detail below)

As noted above, the mid-region residues (S19 Cagri- P25 Cagri ) form the prototypical bypass motif that was observed for rAmy/San385, constrained by conserved intramolecular hydrogen bonds between the backbone of L16 Cagri /F23 Cagri and S20 Cagri , and the backbone of P25 Cagri and N21 Cagri (Fig

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Assay Type: Competitive Inhibition

Mechanisms regulating melanogenesis