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Relevant studies confirm that activation of OR1A2 on human alveolar macrophages suppresses secretion of pro-inflammatory cytokines CXCL-8 and IL-6 ( 4.4.2 Airway remodeling: inflammation-driven structural reprogramming Airway remodeling in COPD represents a dynamic inflammatory-driven restructuring process, with pathological crosstalk between epithelial cells and smooth muscle cells constituting its core mechanism

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491 In contrast, PGC-1 overexpression or activation following IRI facilitates the recovery of renal function and tubule homeostasis