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Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: protection by melatonin

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The induction of HO-1 can reduce the production of reactive oxygen species, thereby reducing oxidative stress and inflammation

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Figure 7)

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A pharmacokinetic study in rats found that oral administration produced substantial plasma concentrations, with a maximum concentration of 2252 ng/mL and an elimination half-life of approximately 6.9 hours

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