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(1990) demonstrated the fundamental synergistic interaction between GHRH and GH secretagogues at the pituitary level, showing that combined administration produced supra-additive GH responses in both animal and human models [1]

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Research indicates that liposomal formulations delivered using iontophoresis significantly enhance the transdermal transport of encapsulated proteins (such as platelet-rich plasma), propranolol, diclofenac, and peptides in both porcine and human skin, surpassing passive diffusion methods [251253]