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Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins)

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In addition, curcumin is known as a generally recognized as safe substance ( Challenges and limitations Despite its promising therapeutic potential, curcumin exhibits poor aqueous solubility (11 ng/mL), chemical instability at neutral to alkaline pH, and low oral bioavailability due to rapid hepatic metabolism and systemic elimination

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