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However, the diversity of combinations and dosing regimens complicates the interpretation of results and hinders the establishment of standardized treatment protocols [51]

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In human endothelial cells and animal models, empagliflozin enhances mitochondrial membrane potential, reduces mtROS production, and upregulates antioxidant enzymes (e.g., SOD2, catalase) via AMPK and Nrf2 activation

Because these effects overlap, patients often notice improvements across the board skin, healing, and hair rather than in just one area