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We hypothesize that a decrease in CO and/or other possibly protective smoking byproducts, either due to quitting all forms of smoking or switching fully or partially from regular cigarettes to e-cigarettes (or other nicotine delivery systems, such as chewing tobacco, snuff, or snus), may have contributed to the recent increase in ANA in the US

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Bover, M.T., et al., Waking at night to smoke as a marker for tobacco dependence: patient characteristics and relationship to treatment outcome

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