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Maybe the answer is simply that they could not afford not to, or in other words that they had to pay more than they could really afford for something they did not altogether want

Working in sequence, each protein played a distinct role: one attached a glucose molecule to nicotinic acid, a second chemically primed that tagged compound for the ring-joining reaction, a third steered the chemistry toward the correct mirror-image form of nicotine, and a fourth snipped the glucose back off to release the finished product

Now I admire his commitment but at the time I shuddered

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