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Nicotine in diseases Smoking inserts a high amount of xenobiotics, which in turn can alkylate DNA, activate specific (anti)inflammatory signals, and oxidative stress in active smokers and also second-hand smokers [167, 168]

The National Institutes of Healths Smokefree.gov website offers ideas on developing a quitting plan, an online text app with reminders related to the plan, and a mobile phone app to track cravings and experiences

The best way to reduce harm from tobacco is to quit smoking entirely, rather than switching to another tobacco product that still delivers nicotine and other harmful chemicals