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Nicotine and angiogenesis Nicotine acting on 7 nAChRs acutely enhances angiogenesis, promoting endothelial cell migration, proliferation and survival, and enhances the angiogenic response to inflammation, ischemia, and atherosclerosis.(15) On the other hand chronic nicotine treatment in rodents found impairment rather than enhanced angiogenesis mediated by downregulation of vascular nAChRs.(16)

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