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They found that increased ROS production in mitochondria damages mtDNA, leading to mitochondrial dysfunction

Co-author Wenming Dong, a research scientist in Berkeley Labs Earth and Environmental Sciences Area (EESA), used an advanced triple quadrupole inductively coupled plasma mass spectrometry (QQQ ICP-MS) system in the EESA Aqueous Geochemistry lab to detect significant levels of 28 trace metals in secondhand and thirdhand smoke

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"Sorry, but I can't ignore it when it happens in front of me," he wrote.

Diagnosis can be confirmed using molecular genetic techniques to verify mutation of FERMT.5,13 That this type of analysis was not feasible in our patients was one of the limitations of the study