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If your macrophages are exhausted from a terrible diet, heavily stressed, and lacking sleep, no amount of signaling will perfect the healing process

Ann Oncol 18:14571466 Darcy MS (2019) Cell death: a review of the major forms of apoptosis, necrosis and autophagy

That is an important framing for anyone tempted to treat it as a shortcut: even in the animal work that generates the interest, the compound is one input alongside energy balance, not a replacement for it

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