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New blood vessel formation brings oxygen, nutrients, and immune cells to injured tissues

Figure 4 GSTM3 Inhibited PC Cell Proliferation in vivo The xenograft tumor model was applied to explore the effect of GSTM3 on cell proliferation in vivo

While generally considered safe, long-term or high-dose DFO administration can still lead to neurotoxicity or organ damage (Zhang et al., 2025), and it requires slow infusion due to the risk of hypotension ( In summary, while systemic IV DFO is invasive and non-specific for brain delivery for chronic brain iron overload, it may have potential applications for immediate effect and is useful in acute neurological damage where iron is rapidly released and accessible (e.g., acute iron poisoning or ICH)

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The exact mechanism by which hesperidin reduced the iron induced oxidative stress is not clearly known