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Herein, the mh-Tyr crystal structure was also processed by deletion of co-crystallized ligand and water molecules, the addition of polar hydrogen atoms, optimization of hydrogen-bonding network rotation of thiol and hydroxyl hydrogen atoms, tautomerization and protonation states for histidine (His) residue, assignments of Chi flip for asparagine (Asn), glutamine (Gln), and His residues, and optimization of hydrogen atoms in distinct species achieved by the Protein preparation wizard

Glutathione is a widely used antioxidant known for its powerful skin-brightening and anti-aging properties

JAS holds a CONICET fellowship

Since some adverse effects such as serious infections and skin cancers were reported, additional evaluation of the safety profile of this drug is needed (Gordon 2012

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