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Conversely, defective autophagy exacerbates inflammatory responses, further aggravating insulin resistance in women with PCOS ( 3.3 Ferroptosis Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, may play a key role in the pathogenesis of PCOS

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Ann NY Acad Sci 1993

Glutathione stops the superoxide, free radicals, hydrogen peroxides, lipid peroxides, and peroxynitrites that cause this lipid oxidation