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4 AokiM.MorishitaR.TaniyamaY.KidaI.MoriguchiA.MatsumotoK.et al (2000)

The copper ion is coordinated through the histidine and lysine residues, creating a stable complex that demonstrates enhanced biological activity compared to the peptide alone

When formulated together, niacinamides anti-inflammatory and barrier-strengthening properties help improve tolerability of tretinoin, reducing common side effects like dryness and irritation

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Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development