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The tripeptide backbone consists of three endogenous amino acids (glycine, histidine, lysine), and the copper(II) coordination does not fundamentally alter the metabolic fate of the backbone peptide

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Results from a randomized, double-blind clinical trial involving eighty critically ill patients with severe pneumonia showed that giving them an intravenous dose of vitamin C is safe and can lower inflammation, lengthen the time they need for mechanical ventilation, and decrease their use of vasopressors without having a significant impact on death [49]

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their reduction is achieved by Trx