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Current evidence includes: Laboratory studies Animal research Cell signaling research Small human studies Cosmetic and regenerative medicine observations More large-scale human clinical trials are still needed

These ligands are distributed downstream due to convective flow, resulting in an autologous chemotaxis mechanism, which can direct tumor cells towards the draining lymphatics, facilitating their metastatic spread [233]

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Much of the clinical work with DSIP has been small scale, in specific populations (e.g., chronic insomniac patients, disturbed human sleep), and sometimes with injections in hospital/lab settings