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SARS-CoV-2 also inhibits nuclear factor-erythyroid 2 p45-related factor 2 (Nrf2), a primary transcription factor critical in increasing expression of glutamate cysteine ligase (GCL) [101-103]

Kravetz RE

It has been postulated that glutathione can counter this oxidative stress and help alleviate the cytokine storm associated with COVID-19 [Table 2].[] GLUTATHIONE SUPPLEMENTATION IN PREGNANCY AND LACTATION As per the data available, there is no conclusive evidence of use of glutathione in pregnancy and lactation

Subsequently, innate immune cells in the brain (microglia, astrocytes, and oligodendroglia) are activated in response to inflammatory stimuli including the production of cytokines, chemokines, and secondary inflammatory mediators such as prostaglandins (77)

Kinetics of uptake and deacetylation of N-acetylcysteine by human erythrocytes