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For example, when using drugs with potential systemic adverse reactions, cream formulations can reduce the burden on important organs such as the liver and kidneys of patients

doi: 10.1186/s12929-024-01026-5

Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives

Gall, W

Cloning and characterization of the proximal promoter region of the mouse glutamate-l-cysteine ligase regulatory subunit gene