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Mice were euthanized and blood was collected by cardiac puncture and processed immediately for simultaneous determination of EtOH and acetaldehyde by headspace gas chromatography/mass spectrometry (HS-GC/MS) analysis

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NNMT becomes a metabolic problem when it is overexpressed which is precisely what happens in obesity

When to Adjust Dosing Increase dose if: After 4-6 weeks at current dose, no measurable body composition changes occur, youre tolerating current dose without side effects, youre below the upper clinical range (1 mg daily), and your physician approves escalation based on comprehensive assessment

doi: 10.1016/j.jff.2020.104103