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A: Many users see changes within 46 weeks of consistent use

Total RNA was extracted from cell samples using TRIzol (Invitrogen)

doi:10.1177/1753465812437563 Tse HN, Raiteri L, Wong KY, et al

Interestingly, when we went through the process and indicated that our main concern is dark spots, that were as healthy as a horse, but that weve never used hydroquinone before, it actually recommended an entirely different product called Future Formula RX, which contains tretinoin (a prescription-level version of retinol), azelaic acid, tranexamic acid, niacinamide, and dexpanthenolbut no hydroquinone

Important context on these results Several caveats keep these numbers honest