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Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)

Check for drug interactions - Some prescriptions, like proton pump inhibitors, can impact B12 absorption and may need to be changed

This is why one of the very first recommendations here at iThrive is a strict trial without gluten for at least 8 to 12 weeks

*Correspondence: Antonio Kokot, [email protected]