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Moreover, the combination of novel drugs with existing treatment modalities (e.g., SGLT2 inhibitors with ferroptosis inhibitors, antioxidants like selenocysteine with Ferrostatin-1 or Liproxstatin-1, and GLP-1 receptor agonists with ferroptosis inhibitors) (207209) will be an important area of future research

LMGC is the recipient of a CAPES doctoral scholarship

Furthermore, in colorectal cancer, ROS generated from inflammatory cells, such as neutrophils and macrophages, play a critical role in the progression of colorectal cancer by inducing DNA damage, promoting epithelial cell proliferation, and impairing apoptosis

It recommends that glutathione infusions be reserved for specific medical conditions and conducted under close supervision

Data were collected in Full MS mode at a resolution setting of 70,000 and scanning 1101000 m / z with a heated ESI source set to instrument defaults for a 400 L/min flow rate