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Stop taking Vitamin B12 Injection and call your doctor at once if you have one of these serious side effects: Congestive heart failure Low potassium levels in body Narrowing or blocking of blood vessels Pulmonary edema (a condition where there is excess fluid in the lungs) Serious allergic reaction Thrombocytosis (a disorder where your body produces too many platelets) Less serious side effects include headache, nausea, anxiety, nervousness, diarrhea, swelling, infection, severe itching of skin, loss of coordination and balance