Alpha-tocopherol is believed to be the first part of an antioxidant network (shown below) where it is oxidized to donate an electron to stabilize reactive oxygen species
The application of autophagy-related molecules as therapeutic targets to counteract DOR is still in its early stages and warrants additional research to clarify both their therapeutic potential and associated risks
Eur J Drug Metab Pharmacokinet 47(1):118 Ghavami S, Kerkhoff C, Los M, Hashemi M, Sorg C, Karami-Tehrani F (2004) Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions
Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson's disease: a randomised controlled trial
Treatment with hederagenin in lung cancer cells, leads to a strong upregulation of the CHAC1 gene even though basal CHAC1 expression is significantly lower than in normal tissues (Lu et al., 2024)
