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The majority of the published literature examines each compound independently, and the synergy hypothesis, while mechanistically well-supported, has not yet been the subject of large-scale controlled studies

Men with higher urinary BPA concentrations showed altered thyroid and reproductive hormone profiles, suggesting endocrine disruption at environmentally relevant exposure levels ( 4.1.1.2 Biomarker and mechanistic evidence Comprehensive biomarker studies have established clear links between phthalate exposure and sperm DNA integrity

Moon, K

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