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Physical symptoms may include weakness, pale or yellowish skin, numbness or tingling in extremities, balance difficulties, mood changes including depression or irritability, and tongue inflammation

Among these, thymosin beta-4 (TB-4) and its shorter synthetic fragment TB-500 are increasingly central to regenerative biology research

Experimental & Molecular Medicine, 48 (4), e224

In parallel, studies have reported modulation of early growth response-1 (EGR-1) expression and its regulatory partner NAB2, which are involved in cytokine signaling and early extracellular matrix formation during cellular response processes [2]

But stress, aging, hormones, inflammation, poor nutrition, and environmental damage can interfere with this natural process