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JCI Insight 3 , 99276 (2018)

doi: 10.1016/j.ghir.2022.101482 129 ArreseMCabreraDKalergisAMFeldsteinAE

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In summary, microbial dysbiosis contributes to the onset and progression of LN by disrupting the intestinal barrier integrity and promoting systemic immune activation

Another study reported that, in children with fever, the area under the serum concentration-time curve (AUC) increased by 1344% from first dose to steady state implying that paracetamol may accumulate in this patient group although no hepatotoxicity was demonstrated [48]