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In addition to inducing P450 enzymes, phenobarbital can also induce glutathione S-transferase A1/A2 (rGSTA1/A2)

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Specifically, NAC exponentially increases the production of specialized detoxification enzymes known as Glutathione S-transferases (GSTs)

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IV use also carries documented risks, including liver and kidney strain and serious skin reactions in case reports, part of why India's drug regulator restricted its cosmetic injectable use in 2026

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The AAFP recommends injectable therapy when rapid improvement is needed for severe deficiency or serious neurologic involvement

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